Prostate cancer (PCa) is a common illness for aging males. NCI CPTC Antibody Characterization Program. Lycopene is a phytochemical that is found in colorful fruits and vegetables such as apricots, watermelons, guavas, pink grapefruit, papayas, red carrots, red bell peppers, red cabbage - and of course, tomatoes. Article Health Benefits. Foods High In Lycopene. The benefits. Lycopene has a chemopreventive effect against prostate cancer but its role in prostate cancer progression is unknown; many patients increase their intake of lycopene, although there are no evidence-based guidelines to suggest an effect. Leitzmann MF, Stampfer MJ, Kana W, Graham AC, Walter CW, Giovannucci EL . There are many lycopene supplements available; however, their safety, purity, and efficacy are unknown. Version 2 1999. . Chemopreventive Potential of Dietary Nanonutraceuticals for Prostate Cancer: An Extensive Review. Several years ago, I noticed that lycopene supplements quickly resolved my symptoms of benign prostate enlargement. Lycopene resulted in lowering cancer-related symptoms (pain, urinary tract symptoms), and severe toxicity or intolerance was not evident. 2022 May 17;27(10):3209. doi: 10.3390/molecules27103209. Tomato soup is rich in lycopene, a powerful antioxidant that boosts immune function. Lycopene is more bioavailable from tomato paste than from fresh tomatoes. Prostate Cancer Treatment Using Lycopene. Pharmaceutics. Google Scholar. HHS Vulnerability Disclosure, Help Lycopene is a type of organic pigment called a carotenoid. Currently, there is no recommended daily allowance (RDA) for lycopene intake. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Ansari MS, Gupta NP . Lieberman R, Bermejo C, Akaza H, Greenwald P, Fair W, Thompson I . For many urologic/urogynecologic conditions, dietary changes are often first-line treatments. Be mindful of the sodium content when purchasing or making your tomato sauces. Maturitas. Lycopene as a chemopreventive agent in the treatment of high-grade prostate intraepithelial neoplasia. 2013;59(3):213-23. doi: 10.3177/jnsv.59.213. Disclaimer, National Library of Medicine Copyright 2022. Chen L, Stacewicz-Sapuntzakis M, Duncan C, Sharifi R, Ghosh L, van Breemen R et al. This study aims to determine dietary lycopene con 2022 Greater Boston Urology. The size of the square represents the weight that the corresponding study exerts in the meta-analysis. Consistently, higher circulating lycopene levels significantly reduced the risk of PCa. government site. Am J Clin Nutr 1998; 68: 11871195. Tips for retailers Remember three more points about lycopene: Jack Challem is a personal nutrition coach in Tucson, Ariz. His latest book is Stop Prediabetes Now (Wiley, 2007). Carotenoid content of thermally processed tomato-based food products. For all the reasons outlined above, buying a Lycopene supplement is a waste of money. This site needs JavaScript to work properly. PMC Bookshelf An inverse association was observed between lycopene intake and PSA levels in six studies. Miller EC, Giovannucci E, Erdman JW Jr, Bahnson R, Schwartz SJ, Clinton SK. New Hope Network is part of the Informa Markets Division of Informa PLC. Lycopene/tomato consumption and the risk of prostate cancer: a systematic review and meta-analysis of prospective studies. Phase II randomized clinical trial of lycopene supplementation before radical prostatectomy. Bethesda, MD 20894, Web Policies As a treatment for prostate cancer, supplemental lycopene didn't show major benefit [Source: Jatoi].However, another study has shown patients taking 15 mg of supplemental lycopene, three weeks before surgery to remove the prostate, had improvements in cancerous lesions and decreases in the PSA score (a blood test used to monitor prostate cancer) [Source: Kucuk]. -, Chen W, Zheng R, Zeng H, et al. Bowen P, Chen L, Stacewicz-Sapuntzakis M, Duncan C, Sharifi R, Ghosh L et al. However, the evidence available to date is insufficient to draw a firm conclusion with respect to lycopene supplementation in prostate cancer patients and larger RCTs are required in broader patient groups. 8. Advances in Food Technology and Nutrition Sciences Open Journal, 6(1), pp.1-12. 8600 Rockville Pike N Engl J Med 1993; 328: 246252. There is also some evidence that increased lycopene consumption can lower the risk of other cancers as well. Benefits of taking Lycopene Rich Foods/Supplements by Prostate Cancer Patients. J Nutr Sci Vitaminol (Tokyo). It has not been definitively proven that lycopene reduces risk of cancer, including prostate cancer. and JavaScript. and transmitted securely. Therefore, eating lycopene with fat will increase . The Plasma Proteome Fingerprint Associated with Circulating Carotenoids and Retinol in Older Adults. doi: 10.1097/MD.0000000000006426. Interestingly, the concentration of circulating lycopene between 2.17 and 85 g/dL was linearly inversed with PCa risk whereas there was no linear association >85 g/dL. Complementary and alternative therapies in prostate cancer. cis-trans isomers of lycopene and beta-carotene in human serum and tissues. This causes problems such as urinary tract infections, bladder stones, incontinence, and acute urinary retention. Google Scholar. The association was indicated as relative risk (RR) with the corresponding 95% confidence interval (CI). 2022 Jan 21;14(2):256. doi: 10.3390/pharmaceutics14020256. The https:// ensures that you are connecting to the Models of DNA structure achieve almost perfect discrimination between normal prostate, benign prostatic hyperplasia (BPH), and adenocarcinoma and have a high potential for predicting BPH and prostate cancer. Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature. You are paying more for less. Eight intervention studies were identified (five with no control group; one with an unmatched control group; and two randomized controlled trials (RCTs)). Zasowska-Nowak A, Nowak PJ, Cialkowska-Rysz A. Nutrients. Including a source of dietary fat with lycopene-containing foods may increase lycopene absorption. Nutr Cancer. Role as an antioxidant and free radical scavenger: according to a meta-analysis based on more than 70 epidemiological studies, "the higher the consumption of tomatoes and tomato products, the lower the risk of cancer". The research Few people paid attention to lycopene until Harvard University researchers published a study in 1995 showing that lycopene-rich foods, such as tomato sauces, were associated with a 35 percent lower risk of developing prostate cancer. Diet and dietary supplement intervention trials for the prevention of prostate cancer recurrence: a review of the randomized controlled trial evidence. Eur Urol 2003; 43: 604608. Mohanty NK, Saxena S, Singh UP, Goyal NK, Arora RP. Number 8860726. Grammatikopoulou MG, Gkiouras K, Papageorgiou S, Myrogiannis I, Mykoniatis I, Papamitsou T, Bogdanos DP, Goulis DG. J Urol 2002; 168: 25052509. Green tea and the risk of prostate cancer: A systematic review and meta-analysis. BJU Int. Bertram JS, Pung A, Churley M, Kappock TJI, Wilkins LR, Cooney RV . Nutr Rev 1999; 57: 182191. Lycopene for the prevention of prostate cancer. Attitudes and adherence to changes in nutrition and physical activity following surgery for prostate cancer: a qualitative study. RR <1 indicates decreased risk of PCa. Kucuk O, Sarkar FH, Sakr W, Khachik F, Djuric Z, Banerjee M et al. Lycopene is a powerful antioxidant that has been shown to offer significant benefits for prostate health. The solid black line and 2 dotted black lines are the restricted cubic spline for the published relative risks (RRs) and 95% confidence intervals (CIs); the short dash straight line is the linear fitting curve used for linear and nonlinear analysis. Would you like email updates of new search results? Lycopene resulted in lowering cancer-related symptoms (pain, urinary tract symptoms), and severe toxicity or intolerance was not evident. Clinton SK, Emenhiser C, Schwartz SJ, Bostwick DG, Williams AW, Moore BJ et al. RR <1 indicates decreased risk of PCa. 2017 Dec;20(4):361-377. doi: 10.1038/pcan.2017.25. Bioavailability and in vivo antioxidant properties of lycopene from tomato products and their possible role in the prevention of cancer. When men suffering from infertility took 2 milligrams of lycopene twice a day for three months, 66% of the men showed improved sperm concentration while 73% showed improved sperm motility (when sperm are . Accessibility Varesi A, Chirumbolo S, Campagnoli LIM, Pierella E, Piccini GB, Carrara A, Ricevuti G, Scassellati C, Bonvicini C, Pascale A. Antioxidants (Basel). Careers. . For maintaining health, 5 to 10 milligrams daily should be sufficient. Chem Biol Interact 2008; 171: 204211. High-dose lycopene supplements can reduce the size of prostate tumors, and may be useful as an adjunct therapy. . Tomato products, lycopene, and prostate cancer risk. The highest concentration of lycopene is found in ketchup and tomato sauces. Chan JM, Elkin EP, Silva SJ, Broering JM, Latini DM, Carroll PR . Dietary patterns identified using factor analysis and prostate cancer risk: a case control study in Western Australia. Ripple MO, Henry WF, Rago RP, Wilding G . RR <1 indicates decreased risk of PCa. MEDLINE, EMBASE CINAHL Plus, Web of Science, AMED and CENTRAL databases were systematically searched using terms for lycopene and prostate cancer progression to identify studies published before January 2009. Nutr Cancer 1999; 33: 159164. Most Americans get most of their lycopene intake from processed tomato products such as ketchup and pasta sauce. Google Scholar. A systematic review. doi: 10.1136/bmjopen-2021-055566. Arch Biochem Biophys 1992; 294: 173177. The RR estimate of each study is marked with a solid black square. In plants, algae, and other . Malins DC, Polissar NL, Gunselman SJ . WCRF-AICR. Urology 2005; 66: 12231228. In the current analysis, baseline height, body mass index, history of prostate cancer, smoking history, total dietary calorie . Prostate carcinogenesis in N-methyl-N-nitrosourea(NMU)-testosterone-treated rats fed tomato powder, lycopene or energy-restricted diets. Lycopene is a naturally occurring antioxidant from the carotenoid family. Furthermore, our dose-response meta-analysis demonstrated that higher lycopene consumption was linearly associated with a reduced risk of PCa with a threshold between 9 and 21 mg/day. Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ et al. FOIA Lycopene: Implications for Human HealthA Review. Many scientific studies carried out over the past few years show that lycopene benefits health by helping to prevent prostate, lung, and stomach cancers. Food, nutrition, physical activity and the prevention of cancer: Global perspective. Bankson DD, Countryman CJ, Collins SJ . Some non-red foods such as asparagus and parsley also contain small amounts of lycopene. Cochrane Database Syst Rev. Jatoi A, Burch P, Hillman D, Vanyo JM, Dakhil S, Nikcevich D et al. However, if you are unable to consume these foods for reasons other than their lycopene content, a lycopene supplement should be considered. Cancer Epidemiol Biomarkers Prev 2007; 16: 21932203. Oh WK, Small EJ . An official website of the United States government. Phase I-II prospective dose-escalating trial of lycopene in patients with biochemical relapse of prostate cancer after definitive local therapy. However, it may be useful to people who cannot eat tomato products. How to use lycopene I favor the natural tomato-based source of lycopene because related compounds such as phytofluene and phytoene are likely to have health benefits. The CIs of pooled estimates are displayed as a horizontal line through the diamond. For maintaining health, 5 to 10 milligrams daily should be sufficient. Please enable it to take advantage of the complete set of features! By Stephen Daniells. Urol Clin North Am. Although lycopene is chemically a carotene, [citation needed] it has no vitamin A activity. Nutrients. The RR estimate of each study is marked with a solid black square. Before Urol Oncol 2004; 22: 415420. 2002 Feb;29(1):83-93. doi: 10.1016/s0094-0143(02)00020-4. Benefits of lycopene Lycopene, found in many fruits and vegetables -- especially tomatoes and watermelon -- may play an important role in reducing risks of many diseases, including prostate cancer and breast cancer. Doseresponse analysis of lycopene consumption and risk of prostate cancer. Abstracts of Presentations at the Association of Clinical Scientists 143. Forest plot for doseresponse association of highest vs. lowest categories of circulating lycopene concentrations and the risk of prostate cancer (PCa). Supplement use among men with prostate cancer. Lycopene and 1,25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells. Angioprevention of Urologic Cancers by Plant-Derived Foods. Carotenoids and gene regulation. J Natl Cancer Inst 2001; 93: 18721879. Unable to load your collection due to an error, Unable to load your delegates due to an error. Epub 2017 Apr 25. Also, variable results were reported for lycopene supplementation in prostate cancer patients . Diet after diagnosis and the risk of prostate cancer progression, recurrence and death (United States). People who are pregnant or breastfeeding may be advised not to take lycopene supplements. Ann Epidemiol 2008; 18:364370. Lycopene's Effect on Prostate Cancer in the Laboratory In laboratory studies, treatment with lycopene damaged prostate cancer cells, causing them to grow much slower. J Urology 2008; 180: 23142322. There are more benefits to consuming lycopene from whole foods than from a supplement. 2022 Jan 11;152(1):40-48. doi: 10.1093/jn/nxab340. Other causes include urogenital infections, congenital and genetic anomalies, immunologic factors, and endocrine disorders. Our objective was to conduct a systematic review of literature to evaluate the association between . -. Our objective was to conduct a systematic review of literature to evaluate the association between lycopene intake and prostate cancer progression. The https:// ensures that you are connecting to the Epub 2017 Apr 25. Cancer Epidemiol Biomarkers Prev 2004; 13: 260269. Endogenous production of reactive oxygen species during . CAS Suppression by carotenoids of microcystin-induced morphological changes in mouse hepatocytes. The size of the square represents the weight that the corresponding study exerts in the meta-analysis. Prostate Cancer and Prostatic Diseases Rowles JL 3rd, Ranard KM, Smith JW, An R, Erdman JW Jr. Prostate Cancer Prostatic Dis. Uptake of lycopene and its geometrical isomers is greater from heat-processed than from unprocessed tomato juice in humans. Google Scholar. We identified 72 human and animal studies that were then analysed for endpoints . Bertram JS . Colorful vegetable salads and fruit salads are a nutritious way to increase your lycopene intake. CAS Dietary Factors and Supplements Influencing Prostate Specific-Antigen (PSA) Concentrations in Men with Prostate Cancer and Increased Cancer Risk: An Evidence Analysis Review Based on Randomized Controlled Trials. The aim of this systematic review was to examine the effectiveness of lycopene for the prevention and treatment of BPH and prostate cancer. Bookshelf The association was indicated as relative risk (RR) estimate with the corresponding 95% confidence interval (CI). Effect of lycopene on insulin-like growth factor-I, IGF binding protein-3 and IGF type-I receptor in prostate cancer cells. The authors acknowledge Ms Alex McIlroy for her assistance in developing the electronic search strategy used in the systematic review and Ms Helen Mulholland for her support in selecting the relevant articles. and prostate cancers. Kim HS, Bowen P, Chen L, Duncan C, Ghosh L, Sharifi R et al. Pure Appl Chem 2002; 74: 14431450. HHS Vulnerability Disclosure, Help -, Ambrosini GL, Fritschi L, de Klerk NH, et al. Adverse health effects of selenium in humans. Ponholzer A, Struhul G, Maderbacher S . Abbas F, Scardino PT . The STATA (version 12.0) was applied to process the dose-response meta-analysis. Attitudes and use of complementary medicine in men with prostate cancer. Uses of Lycopene. Lycopene: a novel drug therapy in hormone refractory metastatic prostate cancer. Prostate-cancer treatment. Schmitz HH, Poor CL, Wellman RB, Erdman Jr JW . 2022 Jun 22;11(7):1224. doi: 10.3390/antiox11071224. Eisenberg DM, Kessler RC, Foster C, Norlock FE, Calkins DR, Delbanco TL . Stahl W, Sies H . in 2020, supplementation of lycopene had positive effects on cancer markers in 25 (93%) of the studies.[2]. Lycopene is a nutraceutical with health-promoting and anti-cancer activities, but due to a lack of evidence, there are no recommendations regarding its use and dosage. J Agric Food Chem 1992; 43: 579586. Related tags: Lycopene, Prostate cancer . E-mail him, with "NFM" in the subject line, at [emailprotected]. Phytotherapy in Integrative Oncology-An Update of Promising Treatment Options. If tomato is not listed on a lycopene supplement as a source, the lycopene is most likely synthetic. Ann Clin Lab Sci. Parker RS . Whereas a lycopene supplement costs, on average, somewhere between $20 and $60 on Amazon. One of the biggest benefits of lycopene is that it is an antioxidant and protects the body from free radical stress that can damage DNA and other cell structures. government site. Although inverse association between lycopene consumption and PCa risk was not found in all studies, there was a trend that with higher lycopene intake, there was reduced incidence of PCa (P = 0.078). Front Oncol. Food and Drug Administration's evidence-based review for qualified health claims: tomatoes, lycopene, and cancer. The prostate contains the highest concentration of lycopene, suggesting a biological requirement for lycopene in this organ. Provided by the Springer Nature SharedIt content-sharing initiative, Prostate Cancer and Prostatic Diseases (2017), Prostate Cancer and Prostatic Diseases (Prostate Cancer Prostatic Dis) Forest plot for doseresponse association of highest vs. lowest categories of dietary lycopene consumption and the risk of prostate cancer (PCa) after sensitivity analysis and removing one Chinese study. There are more benefits to consuming lycopene from whole foods than from a . Paetau I, Khachik F, Brown ED, Beecher GR, Kramer TR, Chittams J et al. The RR estimate of each study is marked with a solid black square. Carcinogenesis 1991; 12: 671678. Concentrations of selected carotenoids and vitamin A in human liver, kidney and lung tissue. Eighty percent of lycopene comes from processed tomato products such as tomato juice, ketchup, pizza sauce, and tomato sauce. . This review aimed to evaluate the benefits of lycopene supplementation in cancer prevention and treatment based on the results of in vivo studies. The authors have no conflicts of interest to disclose. Serum and tissue lycopene and biomarkers of oxidation in prostate cancer patients: a case-control study. The natural history of clinical prostate carcinoma. Chopra H, Bibi S, Goyal R, Gautam RK, Trivedi R, Upadhyay TK, Mujahid MH, Shah MA, Haris M, Khot KB, Gopan G, Singh I, Kim JK, Jose J, Abdel-Daim MM, Alhumaydhi FA, Emran TB, Kim B. Prostate Power Rx is carefully formulated with important herbs and nutrients to provide optimal prostate health. MeSH Giovannucci E . So there are a few reasons why tomato juice might be good for you. Food Chem Toxicol 2002; 40: 15811588. Several signaling pathways have been identified as players in prostate cancer development. 2022 Jun 29;12(6):e055566. Epub 2016 Feb 22. However, further studies are required to determine the mechanism by which lycopene reduces the risk of PCa and if there are other factors in tomato products that might potentially decrease PCa risk and progression. Proc Natl Acad Sci USA 1997; 94: 259264. Bethesda, MD 20894, Web Policies Lycopene's antioxidant effect may slow down the death of bone cells, strengthen bone architecture, and help maintain bones healthy and strong. Abstract. Clinical studies have found that lycopene also appears to reduce the risk of prostate cancer, and may have therapeutic benefits in men with active prostate cancer. official website and that any information you provide is encrypted sharing sensitive information, make sure youre on a federal Removal of one Chinese study in sensitivity analysis, or recalculation using data from only high-quality studies for subgroup analysis, indicated that higher lycopene consumption significantly lowered PCa risk. Tomatoes are a good source of other nutrients that are important for good health, including vitamin C, potassium, and fiber. Urology 2007; 69: 289294. Exp Biol Med 2002; 227: 881885. The association was indicated as relative risk (RR) with the corresponding 95% confidence interval (CI). 8600 Rockville Pike A comparison of lycopene and orchidectomy vs orchidectomy alone in the management of advanced prostate cancer. Urology 2005; 66: 161166. Kucuk O, Sarkar FH, Djuric Z, Sakr W, Pollak MN, Khachik F et al. Carotenoid and tocopherol composition of human adipose tissue. https://doi.org/10.1038/pcan.2009.38, DOI: https://doi.org/10.1038/pcan.2009.38. A 23-year study in more than 46,000 men looked at the link between lycopene and prostate cancer in more detail. Lycopene is fat soluble. Am J Clin Nutr 1988; 47: 3336. Informa Markets, a trading division of Informa PLC. 1 Mellert W, Deckardt K, Gembardt C, Schulte S, Van Ravenzwaay B, Slesinski RS . Clipboard, Search History, and several other advanced features are temporarily unavailable. A tomato-based, lycopene-containing intervention for androgen-independent prostate cancer: results of a Phase II Study from the North Central Cancer Treatment Group. Biomedicine & Pharmacotherapy, 129, p.110459. Studies investigating the relation between lycopene and PCa risk have produced inconsistent results. diagnosed with an enlarged prostate and reduce the risk of other prostate conditions such as prostate inflammation and prostate cancer. What it is Lycopene is the antioxidant carotenoid that gives tomatoes their red color. An official website of the United States government. Cancer Causes Control 2006; 17: 199208. The CIs of pooled estimates are displayed as a horizontal line through the diamond. Cancer Epidemiology and Prevention Research Group, Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland, UK, Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland, UK, You can also search for this author in In conclusion, our novel data demonstrates that higher lycopene consumption/circulating concentration is associated with a lower risk of PCa. official website and that any information you provide is encrypted Lycopene has been found helpful to various health benefits ranging from promoting prostate health to preventing certain types of cancers. The rates of progression measured by bone scan in one RCT were lower in the intervention group. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Effects of lycopene supplementation in patients with localized prostate cancer. Yamaguchi Y, Zampino M, Tanaka T, Bandinelli S, Moaddel R, Fantoni G, Candia J, Ferrucci L, Semba RD. Eng J, Ramsum D, Verhoef M, Guns E, Davison J, Gallagher R . Zhang L, Cooney RV, Bertram JS . Syed DN, Khan N, Afaq F, Mukhtar H . 2012 Aug;72(4):269-76. doi: 10.1016/j.maturitas.2012.04.014. Urol Oncol. Lycopene is a powerful antioxidant . Lipids 1995; 30: 10291034. All Rights Reserved |, Lycopene & Prostate Health: What You Need to Know, November is National Family Caregivers Month, Surgery for Pelvic Organ Prolapse: Understanding Native Tissue vs. Mesh-Augmented Surgery, national cancer prevention awareness month. In men with high-grade prostatic intraepithelial neoplasia, a lycopene-rich extract did not confer any benefits , and high doses of lycopene, green tea catechins, and selenium were actually associated with higher prostate cancer incidence . Foods that are rich in lycopene are also rich in other antioxidants, vitamins, minerals, and fiber. Among all the carotenoids (over 600 of them), lycopene has the highest free-radical scavenging ability. Prooxidant-antioxidant shift induced by androgen treatment of human prostate carcinoma cells. in a study using tomato-based juice as lycopene source, 80% of the subjects absorbed . Lycopene is a natural compound and carotenoid that is mainly found in bright red fruits and vegetables. Forest plot for doseresponse association of each 10g/dL increase of circulating lycopene concentrations with the risk of prostate cancer (PCa). Rowles JL 3rd, Ranard KM, Smith JW, An R, Erdman JW Jr. Prostate Cancer Prostatic Dis. The size of the square represents the weight that the corresponding study exerts in the meta-analysis. sharing sensitive information, make sure youre on a federal -. The CIs of pooled estimates are displayed as a horizontal line through the diamond. Lycopene (from the neo-Latin Lycopersicum, the tomato species) is a bright red carotenoid hydrocarbon found in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, grapefruits, and papayas.It is not present in strawberries or cherries. BJU Int 2003; 92: 375378. NIH: Maryland, USA. The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence. Tomato juice contains lycopene, a phytonutrient that helps improve sperm quality. Christian M S, Schulte S, Hellwig J . Wilkinson S, Gomella LG, Smith JA, Brawer MK, Dawson NA, Wajsman Z et al. There are many lycopene supplements available; however, their safety, purity, and efficacy are unknown. Registered in England and Wales. VAT will be added later in the checkout.Tax calculation will be finalised during checkout. Common Toxicity Criteria Manual. Arch Biochem Biophys 1996; 336: 19. Am J Clin Nutr 1991; 53 (Suppl): 13. Increased dietary and circulating lycopene are associated with reduced prostate cancer risk: a systematic review and meta-analysis. The RR estimate of each study is marked with a solid black square. Ansari MS, Gupta NP . Lycopene Benefits Prostate cancer It's interesting that lycopene is the most abundant carotenoid present in the prostate. The .gov means its official. Forest plot for doseresponse association of each 5mg/day increase of lycopene intake with the risk of prostate cancer (PCa). Carotenoids up-regulate connexin43 gene expression independent of their provitamin A or antioxidant properties. Haseen, F., Cantwell, M., O'Sullivan, J. et al. Epub 2012 May 23. van Die MD, Bone KM, Emery J, Williams SG, Pirotta MV, Paller CJ. Google Scholar. You are using a browser version with limited support for CSS. Examples include tomatoes, red peppers, watermelon, pink grapefruit, papaya, asparagus, and yellow parsley. Cancer Res 1992; 52: 57075712. Ferlay J, Soerjomataram I, Dikshit R, et al. 2011 Nov 9;2011(11):CD008007. J Natl Cancer Inst 1997; 89: 4048. Lycopene may be the very best supplement for maintaining prostate health. Federal government websites often end in .gov or .mil. All prices are NET prices. Aumenta a imunidade. 2007. Cancer 1997; 80: 827833. Should people only get lycopene from foods, or should people consider lycopene supplements at some point (especially if they don't like foods containing lycopene)? and transmitted securely. ISSN 1476-5608 (online) 2. The CIs of pooled estimates are displayed as a horizontal line through the diamond. The size of the square represents the weight that the corresponding study exerts in the meta-analysis. The site is secure. Previous scientific evidence exhibited that the anti-cancer . It's also found in watermelon and guava. Urology 2006; 67: 12571261. Wu K, Erdman JW, Schwartz SJ, Platz EA, Leitzmann M, Clinton SK et al. Prevention of prostate cancer: lycopene extracted from tomatoes is believed to inhibit DNA synthesis in prostate epithelial cells, suggesting an important role in . Lycopene in the treatment of prostate cancer. CAS Eligible studies published in English up to April 10, 2014, were searched and identified from Pubmed, Sciencedirect Online, Wiley online library databases and hand searching. Lycopene's main health benefit is its antioxidant function. Levy J, Bosin E, Feldman B, Giat Y, Miinster A, Danilenko M et al. volume12,pages 325332 (2009)Cite this article. Twenty-six studies were included with 17,517 cases of PCa reported from 563,299 participants. the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Am J Clin Nutr 1997; 66: 122. Lycopene is a member of the carotenoid family, whose strong anti-oxidant properties have been hypothesised to assist in the prevention and treatment of BPH and prostate cancer. 2022 May;52(3):511-525. Lycopene has been identified as an antioxidant agent with potential anticancer properties. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Secure valuable lycopene benefits prostate on Alibaba.com at alluring offers. MEDLINE, EMBASE CINAHL Plus, Web of Science, AMED and CENTRAL databases were systematically searched using terms for lycopene and prostate cancer progression to identify studies published before January 2009. Insufficient Lycopene Intake Is Associated With High Risk of Prostate Cancer: A Cross-Sectional Study From the National Health and Nutrition Examination Survey (2003-2010). It has plenty of health benefits, including improving prostate, eye, brain, skin and heart health. There are also reports of allergic reactions to lycopene, such as skin rashes. Lycopene shows a very few side effects including diarrhea, gassiness . They ate a daily serving of tomato sauce starting three weeks before surgery and the researchers were amazed by the results. Clipboard, Search History, and several other advanced features are temporarily unavailable. BMJ Open. Chronic ingestion of lycopene-rich tomato juice or lycopene supplements significantly increases plasma concentrations of lycopene and related tomato carotenoids in humans. The use of PSA as biomarker in nutritional intervention studies of prostate cancer. Garca-Caballero M, Torres-Vargas JA, Marrero AD, Martnez-Poveda B, Medina M, Quesada AR. Diverse carotenoids protect against chemically induced neoplastic transformation. If you have a condition such as overactive bladder, interstitial cystitis, or reflux, consuming acidic foods, such as tomato products, may increase symptoms. Please enable it to take advantage of the complete set of features! Chronic prostatitis, for example, due to infections, is a suggested risk factor for prostate cancer. But lycopene is best known for its role in helping reduce the risk of prostate cancer. Lycopene: a logical supplement for prostate problems, The Analysts Take: Top takeaways from NBJs Herbs and Botanicals Report, New Hope Network breaks out crystal ball for 2023, FDA review calls for structural changes, increased funding, UNFI posts Q1 sales gains, but profits decline, Unboxed: 23 natural products convenience store shoppers will love, Applegate goes all in for regenerative agriculture with a hot dog, Nominations open for the 2023 Expo West NEXTY Awards, Helping brands understand the sustainable consumer mindset download. Random effects models were used to calculate pooled relative risks (RRs) and 95% confidence intervals (CIs) and to incorporate variation between studies. [1], There is not a conclusive yes or no to this question. This article looks at the health benefits and top food sources of lycopene. Zimmermann-Klemd AM, Reinhardt JK, Winker M, Grndemann C. Molecules. In addition to functioning as an antioxidant, lycopene also helps maintain communication between cells, an attribute that cancer cells lack. Cis-trans lycopene isomers, carotenoids, and retinol in the human prostate. Web page addresses and e-mail addresses turn into links automatically. Abstract. The solid, MeSH Prostate cancer is one of the top three cancers in men. Lycopene inhibits DNA synthesis in primary prostate epithelial cells in vitro and its administration is associated with a reduced prostate-specific antigen velocity in a phase II clinical study. Thank you for visiting nature.com. The solid black line and 2 dotted black lines are the restricted cubic spline for the published relative risks (RR) and 95% confidence intervals (CIs); the short dash straight line is the linear fitting curve used for linear and nonlinear analysis. doi: 10.1002/14651858.CD008007.pub2. Nutr Cancer 2003; 47: 4047. 2020 Sep 29;12(10):2985. doi: 10.3390/nu12102985. The association was indicated as relative risk (RR) with the corresponding 95% confidence interval (CI). Accessibility Lycopene interferes with cell cycle progression and insulin-like growth factor I signaling in mammary cancer cells. Lycopene is a well-known compound found commonly in tomatoes which brings wide range of health benefits against cardiovascular diseases and cancers. 09-Jan-2008 - Last updated on 19-Jul-2008 at 17:23 GMT . Fresh tomatoes, watermelon, grapefruit, and papaya contain the largest amount of lycopene per 100 grams (2.99-3.58mg). Oxidative DNA damage in prostate cancer patients consuming tomato sauce-based entrees as a whole-food intervention. Prevalence, costs, and patterns of use. The new study re-evaluated the dietary questionnaire data from 1986 through 2010. Internet Explorer). Karas M, Amir H, Fishman D, Danilenko M, Segal S, Nahum A et al. Lycopene has been identified as an antioxidant agent with potential anticancer properties. The association was indicated as relative risk (RR) with the corresponding 95% confidence interval (CI). 2021 Dec 13;9:792572. doi: 10.3389/fpubh.2021.792572. Theref PubMedGoogle Scholar. Stahl W, Schwarz W, Sundquist AR, Sies H . Tomato-based sauces can be used in place of higher-fat condiments, such as mayonnaise, ranch dressings, and alfredos. Control Clin Trials 1996; 17: 112. Forest plot for the association of highest vs. lowest categories of dietary lycopene consumption and the risk of prostate cancer (PCa). Lycopene is a promising nutritional component for chemoprevention of prostate cancer (PCa). Lycopene has a chemopreventive effect against prostate cancer but its role in prostate cancer progression is unknown; many patients increase their intake of lycopene, although there are no . A randomized trial of lycopene supplementation in Tobago men with high prostate cancer risk. PMC ISSN 1365-7852 (print), Increased dietary and circulating lycopene are associated with reduced prostate cancer risk: a systematic review and meta-analysis, Prostate cancer progression and mortality: a review of diet and lifestyle factors, Future directions in the prevention of prostate cancer, Prostatakarzinomprophylaxe durch Nahrungsergnzungsmittel, Effect of carotenoid supplementation on plasma carotenoids, inflammation and visual development in preterm infants. Potentiation of the retinoic acid-induced differentiation of HL-60 cells by lycopene. 2017 Dec;20(4):361-377. doi: 10.1038/pcan.2017.25. Prostate Cancer Prostatic Dis 12, 325332 (2009). Carotenoids in Palliative Care-Is There Any Benefit from. J Natl Cancer Inst 2003; 95: 10041007. Cancer Epidemiol Biomarkers Prev 2001; 10: 861868. Stahl W, Sies H . eCollection 2021. National Cancer Institute. Zinc supplement use and risk of prostate cancer. Careers. In . Quality supplement products empower consumer health infographic, Nufargos Berrymune is daily immune support with the power of two superfruits plus vitamins press release, Charlottes Web innovative CBD gummies offer a new frontier for immune support article, Delivering the full power of plants with Phytosome technology article. Nutr Cancer 1999; 33: 105112. This type of cancer is heightened or fueled by testosterone and other male sex hormones which is why the therapy for prostate cancer involves lowering the hormone level in the patient by chemical or surgical means. J Natl Cancer Inst 2003; 95: 15781586. Studies investigating the relation between lycopene and PCa risk have produced inconsistent results. However, the evidence available to date is insufficient to draw a firm conclusion with respect to lycopene supplementation in prostate cancer patients and larger RCTs are required in broader patient groups. Thirteen-week oral toxicity study of synthetic lycopene products in rats. J Natl Cancer Inst 1999; 91: 317331. FOIA Prostate cancer (PCa) is a common illness for aging males. A possibly beneficial role of lycopene in patients diagnosed with benign prostate hyperplasia (BPH), who are at increased risk of developing PCa, has been suggested, although clinical data are lacking. Get time limited or full article access on ReadCube. 2022 Aug 3;14(15):3183. doi: 10.3390/nu14153183. The RR estimate of each study is marked with a solid black square. 2016 Apr;117 Suppl 4(Suppl 4):17-34. doi: 10.1111/bju.13361. . The rates of progression measured by bone scan in one RCT were lower in the intervention group. From an anti-cancer perspective, lycopene is often associated with reduced risk of prostate cancer and people often look for it as a dietary supplement which may help to prevent cancer. In one study, 32 patients with prostate cancer were scheduled to undergo a prostatectomy. Urology 2001; 58: 835842. Rao AV, Fleshner N, Agarwal S . An inverse association was observed between lycopene intake and PSA levels in six studies. PubMed Lycopene helps fight off colds and flu viruses, and it may help prevent cancer. Antioxidants limit the damage free radicals cause by chemically neutralizing them. Our objective was to conduct a systematic review of literature to evaluate the association between lycopene intake and prostate cancer progression. Nutr Cancer 1995; 24: 257266. Article Prostate cancer is a very common cancer among men. F Haseen. Int J Cancer 2015; 136:E359E386. In the body lycopene promotes blood vessel function, supports normal insulin sensitivity, and helps maintain healthy blood pressure levels. The size of the square represents the weight that the corresponding study exerts in the meta-analysis. This study aims to determine dietary lycopene consumption/circulating concentration and any potential dose-response associations with the risk of PCa. The linear and nonlinear dose-response relations were evaluated with data from categories of lycopene consumption/circulating concentrations. Prostate Cancer Prostatic Dis 2006; 9: 407413. Chin Clin Oncol 2013; 18:330334. Tomato soup may be beneficial to men who suffer from infertility problems. Today, we're discussing an appropriate topic for Men's Health Month: lycopene and prostate health. Unconventional medicine in the United States. Chin J Cancer Res 2015; 27:212. Forest plot for the association of highest vs. lowest categories of dietary lycopene, Forest plot for doseresponse association, Forest plot for doseresponse association of highest vs. lowest categories of dietary lycopene, Forest plot for doseresponse association of each 5 mg/day increase of lycopene intake, Doseresponse analysis of lycopene consumption, Doseresponse analysis of lycopene consumption and risk of prostate cancer. Plus, in-vitro studies have found that lycopene may reduce risk of prostate cancer by impedance of cell proliferation, apoptosis, and reduction in damage to DNA. 2005 Nov-Dec;23(6):383-5. doi: 10.1016/j.urolonc.2005.05.012. PubMed Semin Oncol 2002; 29: 575584. J Nutr. The .gov means its official. Lycopene has a chemopreventive effect against prostate cancer but its role in prostate cancer progression is unknown; many patients increase their intake of lycopene, although there are no evidence-based guidelines to suggest an effect. Kanagaraj P, Vijayababu MR, Ravisankar B, Anbalagan J, Aruldhas MM, Arunakaran J . Dietary intake of lycopene increases plasma levels of lycopene and protects against LDL (bad)-Cholesterol oxidation. Phytotherapeutic interventions in the management of biochemically recurrent prostate cancer: a systematic review of randomised trials. The lycopene benefits prostate contain beneficial active ingredients that boost users' health status and wellbeing. Does tomato consumption effectively increase the resistance of lymphocyte DNA to oxidative damage? Clark PE, Hall MC, Borden Jr LS, Miller AA, Hu JJ, Lee WR et al. Conclusion. See this image and copyright information in PMC. Lycopene may show benefits against benign prostate hyperplasia (BPH), a condition said to affect more than half of all men over the age of 50, suggests a new study from Germany. Riso P, Pinder A, Santangelo A, Porrini M . Boileau TW, Liao Z, Kim S, Lemeshow S, Erdman Jr JW, Clinton SK . Frequent use of complementary medicine by prostate cancer patients. Because of its multi-targeted health benefits, lycopene has been described as an important nutrient for longevity. J Nutr 1992; 122: 21612166. Total and specific complementary and alternative medicine use in a large cohort of men with prostate cancer. [1] Mirahmadi, M., Azimi-Hashemi, S., Saburi, E., Kamali, H., Pishbin, M. and Hadizadeh, F., 2020. Chan JM, Holick CN, Leitzmann MF, Stampfer MJ, Giovannucci EL . One medium-size tomato contains about 3.7 milligrams of lycopene. A population-based survey of complementary and alternative medicine use in men recently diagnosed with prostate cancer. 2022 Jul 12;12:925379. doi: 10.3389/fonc.2022.925379. The antioxidant properties help balance free radical activity in the body 4 and, in doing so, may reduce the risk of certain diseases. Article In addition, greater efficacy for the circulating lycopene concentration on preventing PCa was found for studies with high quality, follow-up >10 years and where results were adjusted by the age or the body mass index. The concentration of lycopene is higher in processed foods than fresh foods because of the concentration via water loss. Vinceti M, Wei ET, Malagoli C, Bergomi M, Vivoli G . Matsushima-Nishiwaki R, Shidoji Y, Nishiwaki S, Yamada T, Moriwaki H, Muto Y . A previous assessment of the data from this same cohort showed that dietary lycopene was linked to a 20% lower risk of prostate cancer. Disclaimer, National Library of Medicine 13 Lycopene benefits for men and women's health. More support for lycopene's prostate benefits. RR <1 indicates decreased risk of PCa. The size of the square represents the weight that the corresponding study exerts in the meta-analysis. Analysis of the status and trends of prostate cancer incidence in China. Tomato sauce supplementation and prostate cancer: Lycopene accumulation and modulation of biomarkers of carcinogenesis. AICR: Washington DC. Amir H, Karas M, Giat J, Danilenko M, Levy R, Yermiahu T et al. Food Chem Toxicol 2003; 41: 773783. This is a preview of subscription content, access via your institution. Van Petter CL, de Boer JC, Tomlinson Guns ES . Robles LA, Shingler E, McGeagh L, Rowe E, Koupparis A, Bahl A, Shiridzinomwa C, Persad R, Martin RM, Lane JA. Chemoprevention of prostate cancer through dietary agents: progress and promise. This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. How to use lycopene I favor the natural tomato-based source of lycopene because related compounds such as phytofluene and phytoene are likely to have health benefits. The solid black, Forest plot for doseresponse association of highest vs. lowest categories of circulating lycopene, Forest plot for doseresponse association of each 10 g/dL increase of circulating lycopene, Doseresponse analysis of circulating lycopene, Doseresponse analysis of circulating lycopene concentrations and risk of prostate cancer. The CIs of pooled estimates are displayed as a horizontal line through the diamond. However, low intake of lycopene has been associated with prostate cancer as well as other cancers. Lycopene gives many fruits and vegetables their red, pink, orange, and yellow coloring. Giovannucci E, Ascherio A, Rimm EB, Stampfer MJ, Colditz GA, Willett WC . Lycopene for the prevention and treatment of benign prostatic hyperplasia and prostate cancer: a systematic review. J Natl Cancer Inst 1995; 87: 17671776. Lycopene has not only been linked to many health benefits including disease prevention but . Han S, Zhang S, Chen W, et al. Prostate protection may be enhanced with vitamin E, beta-carotene, selenium, saw palmetto (, Allowed HTML tags: . J Natl Cancer Inst 2007; 99:10741085. Potential inhibitory effect of lycopene on prostate cancer. Would you like email updates of new search results? The CIs of pooled estimates are displayed as a horizontal line through the diamond. Epidemiological evidence links lycopene consumption with decreased prostate cancer risk. Intake of carotenoids and retinol in relation to risk of prostate cancer. The association was indicated as relative risk (RR) with the corresponding 95% confidence interval (CI). Lu Y, Edwards A, Chen Z, Tseng TS, Li M, Gonzalez GV, Zhang K. Front Public Health. Lycopene: a biologically important carotenoid for humans? Always discuss the addition of supplements with your doctor. Before Lines and paragraphs break automatically. In one promising study, mice with human prostate cancer cells treated with both chemotherapy and lycopene lived longer and had smaller tumors than those treated with . (3) Lycopene supplementation also increases its content in prostate tissue. Exp Biol Med 2002; 227: 886893. People who consume a high-lycopene diet may be less likely to get prostate cancer, most common in men aged 40 to 50. RR <1 indicates decreased risk of PCa. Federal government websites often end in .gov or .mil. Forest plot for doseresponse association of each 5mg/day increase of lycopene intake with the risk of prostate cancer (PCa) after sensitivity analysis and removing one Chinese study. Lycopene Benefits: Just the Facts. Article Lycopene may also help reduce the risk of heart disease. Guo Y, Zhi F, Chen P, Zhao K, Xiang H, Mao Q, Wang X, Zhang X. The RR estimate of each study is marked with a solid black square. Tonucci LH, Holden JM, Beecher GR, Khachik F, Davis CS, Mulokozi G . (4) The plasma half-life of lycopene is approximately 2 weeks (4). Nutr Cancer 1998; 31: 199203. Wiygul JB, Evans BR, Peterson BL, Polascik TJ, Walther PJ, Robertson CN et al. It is related to beta- carotene and gives some vegetables and fruits (e.g., tomatoes) a red color. Although most men will live J Cancer Res Clin Oncol 2007; 133: 351359. In 27 clinical trials reviewed by M. Mirahmadi, et al. Gartner C, Stahl W, Sies H . The lycopene in tomatoes could help protect against some types of cancer, and the other nutrients . Lycopene is a tiny plant-based nutrient with numerous health benefits Prostate cancer is known to be the top three cancers in men Lycopene may have the ability to prevent or delay cataracts Kucuk O, Sarkar FH, Sakr W, Djuric Z, Pollak MN, Khachik F et al. Eight intervention studies were identified (five with no control group; one with an unmatched control group; and two randomized controlled trials (RCTs)). Increased dietary and circulating lycopene are associated with reduced prostate cancer risk: a systematic review and meta-analysis. Some lycopene supplementation research conducted on men has shown positive results in treating infertility in men. Effects of tomato sauce consumption on apoptotic cell death in prostate benign hyperplasia and carcinoma. [2] Ibid[3] Doyle, L., 2020. Many in-vitro, human, and animal studies suggest that lycopene can decrease production of prostate cancer cells. Integr Cancer Ther 2003; 2: 16. It helps the prostate. Bunker CH, McDonald AC, Evans RW, de la Rosa N, Boumosleh JM, Patrick AL. In the treatment of prostate cancer, 30 milligrams daily seems to be the effective dose, in conjunction with other therapies. Experimental studies have shown that lycopene slows or stops the growth of cancer cells. 2007;57(2):130-7. doi: 10.1080/01635580701274046. Additional possible benefits of lycopene include reduced risk of cardiovascular disease, increased sperm count and motility, and protection of skin from UV radiation.[3]. All rights reserved. To obtain Informa PLC's registered office is 5 Howick Place, London SW1P 1WG. Cancer Epidemiol Biomarkers Prev 1996; 5: 823833. Correspondence to In the meantime, to ensure continued support, we are displaying the site without styles An acute inability to urinate can be a medical emergency and should be treated by a doctor. Doseresponse analysis of circulating lycopene concentrations and risk of prostate cancer. Rao AV, Agarwal S . Plasma and dietary carotenoids, and the risk of prostate cancer: a nested case-control study. Lycopene is a more potent inhibitor of human cancer cell proliferation than either alpha-carotene or beta-carotene. Annual report on status of cancer in China, 2011. 2017 Mar;96(13):e6426. This site needs JavaScript to work properly. Nutr Cancer 2000; 36: 101111. Developmental (embryo-fetal toxicity/teratogenicity) toxicity studies of synthetic crystalline lycopene in rats and rabbits. PubMed tomato-based source of lycopene because related compounds such as phytofluene and phytoene are likely to have health benefits. Kavanaugh CJ, Trumbo PR, Ellwood KC, et al. Am J Clin Nutr 1999; 69: 712718. Lycopene is best absorbed with a little fat, so suggest that customers take supplements with food. . The site is secure. Lycopene Benefits for Prostate Overview Lycopene Benefits for Prostate A large prostate affects the way the bladder empties. Barber NJ, Zhang X, Zhu G, Pramanik R, Barber JA, Martin FL et al. Rev Environ Health 2001; 16: 233251. The prostate contains the highest concentration of lycopene, suggesting a biological requirement for lycopene in this organ. eCollection 2022. van Weerden WM, Schrder FH . Lycopene has a chemopreventive effect against prostate cancer but its role in prostate cancer progression is unknown; many patients increase their intake of lycopene, although there are no evidence-based guidelines to suggest an effect. Progress in prostate cancer chemoprevention: modulators of promotion and progression. Medicine (Baltimore). RR <1 indicates decreased risk of PCa. Unable to load your collection due to an error, Unable to load your delegates due to an error. Is there a benefit from lycopene supplementation in men with prostate cancer? 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