Disclosure forms provided by the authors are available with the full text of this article at NEJM.org. Mielialalkkeit voidaan kytt mys ahdistuneisuuden, pelkotilojen, paniikkihirin, symishiriiden ja pakko The coefficient of variation is expressed as a percentage. Demographic and Clinical Characteristics of the Participants at Baseline. Brachial artery baseline diameter (interaction effect P=0.10), peak shear rate (interaction effect P=0.61), and time to peak dilation (interaction effect P=0.60) were unaffected (TableS3). Records represent the individual paper and note the event at which the paper was presented. more. more. The change in body weight from baseline to week 68 was 15.3 kg in the semaglutide group as compared with 2.6 kg in the placebo group (estimated treatment difference, 12.7 kg; 95% CI, 13.7 to 11.7). more. Kurhade C, Zou J, Xia H, Cai H, Yang Q, Cutler M, Cooper D, Muik A, Jansen KU, Xie X, Swanson KA, Shi PY. 25. Thomas SJ, Moreira ED Jr, Kitchin N, Absalon J, Gurtman A, Lockhart S, Perez JL, Prez Marc G, Polack FP, Zerbini C, Bailey R, Swanson KA, Xu X, Roychoudhury S, Koury K, Bouguermouh S, Kalina WV, Cooper D, Frenck RW Jr, Hammitt LL, Treci , Nell H, Schaefer A, nal S, Yang Q, Liberator P, Tresnan DB, Mather S, Dormitzer PR, ahin U, Gruber WC, Jansen KU; C4591001 Clinical Trial Group. Markers of arterial stiffness and carotid IMT remained unchanged following 6weeks of cessation from IMST or sham training (all P>0.05) (TableS7). Disease surveillance is an epidemiological practice by which the spread of disease is monitored in order to establish patterns of progression. use prohibited. But he was not wrong that mask wearing comes with unintended consequences, such as people touching their faces a lot. ProQuest Healthcare Administration combines full text coverage for over 550 journals with more than 4500 Doctoral Dissertations and Theses. more. Truth Tobacco Industry Documents (formerly known as Legacy Tobacco Documents Library) was created in 2002 by the UCSF Library. Older individuals have a greater risk for cardiovascular diseases, partly because of increases in blood pressure and endothelial dysfunction. July 21, 2022N Engl J Med 2022; 387:205-216 Sjstrm L. Review of the key results from the Swedish Obese Subjects (SOS) trial a prospective controlled intervention study of bariatric surgery. Report Faults Agencys Food Unit for Leaderless Dysfunction. more. Developed for elementary school students, Searchasaurus includes a children's dictionary, encyclopedia, image searching and a visual search. Fraiman J, Erviti J, Jones M, Greenland S, Whelan P, Kaplan RM, Doshi P. Serious adverse events of special interest following mRNA COVID-19 vaccination in randomized trials in adults. Wharton S, Astrup A, Endahl L, et al. This article was published on June 4, 2022, and updated on July 21, 2022, at NEJM.org. Database of Abstracts of Reviews of Effectiveness (DARE) includes abstracts of published systematic reviews on the effects of health care from around the world, which have been critically analyzed according to a high standard of criteria. Repeated shear stress because of the large changes in lung volume may be an important stimulus, but the acute effects of highresistance IMST on arterial blood flow and shear rate have yet to be determined. Cell lysates were then sonicated for 20seconds and incubated on ice for 10minutes. 13. Instead, 42 people in the mask group, or 1.8 percent, got infected, compared with 53 in the unmasked group, or 2.1 percent. Topics covered by GreenFILE include: Full text content is provided through freely available Open Access journal and government publications. Our results provide support for highresistance IMST as a promising lifestyle intervention for improving cardiovascular function and possibly decreasing the risk of CVD and other clinical disorders, such as cognitive dysfunction and chronic kidney disease. We would like to show you a description here but the site wont allow us. 1-800-AHA-USA-1 This study demonstrates that highresistance inspiratory muscle strength training, a novel time and effortefficient lifestyle intervention, lowers blood pressure, improves endothelial function, and promotes adherence in midlife and older adults with abovenormal systolic blood pressure at baseline. Updates and new developments, http://ezproxy.utica.edu/login?url=https://dsm.psychiatryonline.org/. Experts wrote in an accompanying editorial that research should help dispel misinformation about the effectiveness of universal masking requirements to stem viral transmission. Search authoritative medical information using the FirstSearch MEDLINE interface. By continuing to browse this site you are agreeing to our use of cookies. Use Settings and My Library to customize content, Indexes and abstracts US government publications. more. Dr. Jastreboff can be contacted at [emailprotected] or at Yale University School of Medicine, Endocrinology and Metabolism, 333 Cedar St., P.O. Our daytoday CVs for baseline brachial artery diameter and peak brachial diameter are 4.1% and 3.9%, respectively. ); the Comprehensive Weight Control Center, Division of Endocrinology, Diabetes, and Metabolism, Weill Cornell Medicine, New York (L.J.A. Children and staff with hearing difficulties are having trouble communicating and understanding each other., She added, Even teachers who chose to continue wearing a mask prefer there not be a mandate, so they dont have to deal with discipline all day.. Thus, the rate of adherence to IMST observed here is promising compared with corresponding values for conventional forms of aerobic exercise. The outcome of interest (eg, casual SBP, FMDBA) was entered into the model as the dependent variable, whereas time point, group, and the interaction of time point and group were entered as dependent variables. Microsoft pleaded for its deal on the day of the Phase 2 decision last month, but now the gloves are well and truly off. Subacromial decompression versus diagnostic arthroscopy for shoulder impingement: a 5-year follow-up of a randomised, placebo surgery controlled clinical trial ; Long-term NEET among young adults with experience of out-of-home care : A comparative study of three Nordic countries ; Kaikki julkaisut Previous clinical (based on COVID-19 symptoms/signs alone, if a SARS-CoV-2 NAAT result was not available) or microbiological (based on COVID-19 symptoms/signs and a positive SARS-CoV-2 NAAT result) diagnosis of COVID 19, History of chronic smoking within the prior year, Anticipating the need for immunosuppressive treatment within the next 6 months. Our laboratory's daytoday CVs for 24hour SBP and DBP are 2.5% and 3.3%, respectively. Full text content is restricted to current Utica College students, faculty and staff. For Sources of Funding and Disclosures, see page 14. Americans today are increasingly connected to the world of digital information while on the go via smartphones, tablets and other mobile devices. Hill and Others More from the week of September 16, 2021 Gallbladder-related disorders (mostly cholelithiasis) were reported in 2.6% and 1.2% of participants in the semaglutide and placebo groups, respectively. Obesity is a global health challenge with few pharmacologic options. Observation periods included the in-trial period (the time from random assignment to last contact with a trial site, regardless of treatment discontinuation or rescue intervention) and the on-treatment period. Demographics and baseline characteristics were similar in the two treatment groups (Table 1). Clin Obes 2017;7:273-289. Continuous end-point analyses were conducted with the use of the analysis-of-covariance method, with randomized treatment as a factor and baseline end-point value as a covariate and a multiple imputation approach for missing data.15 Analyses of categorical end points were conducted with the use of logistic regression, with the same factor and covariate. Efficacy end points were analyzed in the full analysis population (all randomly assigned participants according to the intention-to-treat principle); safety end points were analyzed in the safety analysis population (all randomly assigned participants exposed to at least one dose of semaglutide or placebo). Glucagon-like peptide-1 receptor analogues in type 2 diabetes: their use and differential features. Investigator site staff or Pfizer employees directly involved in the conduct of the study, site staff otherwise supervised by the investigator, and their respective family members. NO bioavailability was significantly greater after treatment in the IMST versus sham group (P=0.01) (Figure5A). bars indicate standard errors. Subscribe to the free Science.gov Alert Service and up to 25 relevant results from selected information services will be delivered to you every week. From 2008, The "Times" in full-image content of every page. Yang J, Hu J, Zhu C. Obesity aggravates COVID-19: a systematic review and meta-analysis. The protocol (available with the full text of this article at NEJM.org) was approved by an independent ethics committee or institutional review board at each study site. In addition to clinical and social psychology, it also provides coverage of related disciplines including genetics, psychology of business and economics, communication, criminology, addiction, neurology, social welfare, and more. A great resource for beginning your research. ), and the Department of Diabetes and Endocrinology, Guys and St. Thomas NHS Foundation Trust (B.M.M. 2021;10:e020980. 31. Twentysix participants were either excluded or withdrew before study randomization. This suggests that along with inhibiting ROS production and oxidative stress, IMST may lower BP and/or improve endothelial function by suppressing proinflammatory signaling. Microsoft pleaded for its deal on the day of the Phase 2 decision last month, but now the gloves are well and truly off. The UC Library Catalog offers information about all the Library Collections. N Engl J Med 2011;365:1597-1604. As Ive said before, reasonable and persuasive cases can be made both for and against the use of masks in the healthy population. The most effective and engaging way for clinicians to learn, improve their practice, and prepare for board exams. This work was supported by National Institutes of Health awards R21AG061677, T32DK007135, UL1TR002535, P30CA046934 and American Heart Association Award 18POST33990034. Clase indexes documents published in Latin American journals specializing in the social sciences and humanities. 2021 Apr;592(7853):283-289. doi: 10.1038/s41586-021-03275-y. Millions of full-text articles, many with images. To further interrogate the circulating factors that may be mediating the response to IMST, targeted plasma metabolomics was performed. Critical management issues for those charged with providing enterprise-wide security. Chan School of Public Health. We enrolled adults (18 years of age or older) with one or more self-reported unsuccessful dietary efforts to lose weight and either a BMI of 30 or greater or a BMI of 27 or greater with one or more treated or untreated weight-related coexisting conditions (i.e., hypertension, dyslipidemia, obstructive sleep apnea, or cardiovascular disease). This multidisciplinary database covers the spectrum of academic disciplines and is designed for the academic researcher. Six weeks after cessation of IMST, casual SBP in the subgroup remained significantly lower (1284mmHg, P<0.01) than baseline and not different from endintervention (P=0.71). From 2008, The "Times" in full-image content of every page. Millions of articles available in both PDF and HTML full-text with no restrictions; updated daily. ); and the Division of Endocrinology, Feinberg School of Medicine, Northwestern University, Chicago (R.F.K.). The content of this site is intended for health care professionals. Public health officials have created a giant long-Covid industrial complex, spending billions on MRIs & blood tests that have yielded zero clinical useful info. (%), No. Diabetes Care 2019;42:1912-1920. But a Boston parents group, BPS Families for Covid Safety, has already called for reinstating of universal masking in schools, saying that the new study provides evidence that the practice protects against both illness and lost days of learning in a district where vaccination rates are relatively low and families come from communities that have suffered disproportionately during the pandemic. In the subjects that completed followup testing, FMDBA returned to baseline levels after 6weeks of cessation from IMST; other brachial artery characteristics were unchanged at the followup time point. This collection consists of 6 individual databases that may be searched independently or in any combination. more. 34. S3). 24. more. Garvey WT, Mechanick JI, Brett EM, et al. We would like to show you a description here but the site wont allow us. Intended for K-12 teachers, administrators, and librarians. ), CDC chief Robert Ray Redfield Jr. has gone further than Fauci, declaring in public testimony that this face mask is more guaranteed to protect me against COVID than when I take a COVID vaccine. Two estimands the treatment policy estimand (traditional intention-to-treat analysis, with effects assessed regardless of treatment discontinuation or rescue intervention) and the trial product estimand (effects assessed if the drug or placebo was taken as intended) were used to assess treatment efficacy from different perspectives and accounted for intercurrent events and missing data differently, as described previously.16 All analyses in the statistical hierarchy were based on the primary treatment policy estimand (details on analysis methods are provided in the Supplementary Appendix). more. Audiences include citizens, businesses and nonprofits, federal employees, and government-to-government. Serious adverse events were reported in 9.8% and 6.4% of semaglutide and placebo participants, respectively (Table 3), with the difference due primarily to a difference between the groups in the incidence of serious gastrointestinal disorders (1.4% of participants in the semaglutide group and 0% in the placebo group) and hepatobiliary disorders (1.3% with semaglutide and 0.2% with placebo). Magkos F, Fraterrigo G, Yoshino J, et al. N Engl J Med. It was built to house and provide permanent access to tobacco industry internal corporate documents produced during litigation between US States and the seven major tobacco industry organizations and other sources. Thirtyeight participants were equally randomized to each group, with 36 subjects (n=18 [9 men/9 women] IMST, n=18 [10 men/8 women] sham) included in the final analysis. Our trial showed that among adults with overweight or obesity (without diabetes), once-weekly subcutaneous semaglutide plus lifestyle intervention was associated with substantial, sustained, clinically relevant mean weight loss of 14.9%, with 86% of participants attaining at least 5% weight loss. of coexisting conditions at screening no. To assess the influence of circulating factors on eNOS activation for increasing NO bioavailability, HUVECs treated with 10% subject serum were washed in icecold PBS and incubated with icecold RIPA buffer containing protease and phosphatase inhibitors (Thermo Fisher) for 10minutes. Coprimary, Confirmatory, and Selected Supportive Secondary and Exploratory End Points for the Treatment Policy Estimand. All reported results are for the treatment policy estimand, unless stated otherwise. The grouptime point interaction for PIMAX was P=0.06. 28. more. CFPWV was calculated by subtracting the distance from the suprasternal notch and the carotid measurement site from the distance between the suprasternal notch and the femoral measurement site, and dividing the resultant distance by the aortic transit time.49 Our laboratory's daytoday CV for CFPWV is 5.4%. PubMed provides access to bibliographic information that includes MEDLINE, OLDMEDLINE, as well as: PubMed Central (PMC) is a free digital archive of life sciences journal literature. The efficacy of edaravone for the treatment of ALS was demonstrated in a six-month clinical trial conducted in Japan. The coprimary end points were the percentage change in body weight from baseline to week 68 and achievement of a reduction in body weight of 5% or more from baseline to week 68. A digital journal for innovative original research and fresh, bold ideas in clinical trial design and clinical decision-making. Subject characteristics for the 29 subjects who completed followup testing were similarly wellmatched, with no differences between groups or changes across the intervention (TableS1; all P>0.05). (%), Lipid levels geometric mean mg/dl (coefficient of variation), Estimated glomerular filtration rate geometric mean ml/min/1.73 m, Coexisting conditions at the time of screening, Asthma or chronic obstructive pulmonary disease no. Resource for physical therapy students, educators, and those in practice seeking to maintain certification. All outcome measures were obtained after a >12hour fast from food and caffeine (water allowed), and >24hour abstention from alcohol, physical activity, dietary supplements, and overthecounter medications. Americans today are increasingly connected to the world of digital information while on the go via smartphones, tablets and other mobile devices. Unauthorized Microsoft pleaded for its deal on the day of the Phase 2 decision last month, but now the gloves are well and truly off. Effects of moderate and subsequent progressive weight loss on metabolic function and adipose tissue biology in humans with obesity. Baseline scores are reported for 1296 participants in the semaglutide group and 650 participants in the placebo group. Teacher's Reference Center (TRC) provides indexing and abstracting to the most popular teacher and administrator trade journals, periodicals and books. Produced by the Buros Institute of Mental Measurements at the University of Nebraska. We got an email a few weeks ago from school officials saying they were strongly encouraging masks because of wastewater testing showing high amounts of virus, Ms. Horsley said. more. Includes a knowledgebase. Print Subscriber? The most advanced way to teach, practice, and assess clinical reasoning skills. ArticleFirst is OCLC's index of articles taken from the table of contents pages of journals. Disease surveillance is an epidemiological practice by which the spread of disease is monitored in order to establish patterns of progression. Food and Drug Administration. Critics have argued that there is no strong evidence to prove that masks slow the spread of Covid, and that in any case children werent wearing the right kinds of masks or werent wearing them properly. The study consisted of a 6week randomized, doubleblind, shamcontrolled, paralleldesign clinical trial. This historical dictionary offers etymological analysis, listings of variant spellings and shows pronunciation using the International Phonetic Alphabet. Although the DXA data we report provide greater insight into the weight-loss effects of semaglutide, such assessments were performed in only a subpopulation of participants. This article is commented on by the following: Epidemiology of cardiovascular disease in the United States: implications for the perfusion profession. 26. Subjects covered include: The GeoRef database covers the geology of North America from 1693 to present and the geology of the rest of the world from 1933 to present. National Center Masking may cause communication problems and delays in speech development, may be particularly onerous for children with learning disabilities and makes it difficult to read or communicate emotional expressions, critics have said. Both diet and activity were recorded daily in a diary or by use of a smartphone application or other tools and were reviewed during counseling sessions. S8). Phase 1 only: Individuals at high risk for severe COVID-19, including those with any of the following risk factors: To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Full text articles include charts, diagrams, graphs, tables, photos, and other graphical elements. Flowmediated dilation and cardiovascular risk prediction: a systematic review with metaanalysis, Noninvasive endothelial function testing and the risk of adverse outcomes: a systematic review and metaanalysis, Prognostic value of flowmediated vasodilation in brachial artery and fingertip artery for cardiovascular events: a systematic review and metaanalysis, Habitually exercising older men do not demonstrate ageassociated vascular endothelial oxidative stress, Dietary sodium restriction reverses vascular endothelial dysfunction in middleaged/older adults with moderately elevated systolic blood pressure, Weight loss alone improves conduit and resistance artery endothelial function in young and older overweight/obese adults, Aerobic exercise training and vascular function with ageing in healthy men and women, Effects of different types of exercise training followed by detraining on endotheliumdependent dilation in patients with recent myocardial infarction, Impact of physical training and detraining on endotheliumdependent vasodilation in patients with recent acute myocardial infarction, Creactive protein and other circulating markers of inflammation in the prediction of coronary heart disease, Sympathetic nerve activity in obstructive sleep apnoea, Time course of change in vasodilator function and capacity in response to exercise training in humans, Passive heat therapy improves endothelial function, arterial stiffness and blood pressure in sedentary humans, Aortic stiffness in aging and hypertension: prevention and treatment with habitual aerobic exercise, Trends in adherence to the physical activity guidelines for Americans for aerobic activity and time spent on sedentary behavior among US adults, 2007 to 2016, Journal of the American Heart Association, International Journal of Environmental Research and Public Health, South Russian Journal of Therapeutic Practice, TimeEfficient Inspiratory Muscle Strength Training Lowers Blood Pressure and Improves Endothelial Function, NO Bioavailability, and Oxidative Stress in Midlife/Older Adults With AboveNormal Blood Pressure, Translational Potential of High-Resistance Inspiratory Muscle Strength Training, The Relationship Between Arterial Stiffness and Resistance Training, Time-efficient, high-resistance inspiratory muscle strength training for cardiovascular aging, Visceral Therapy and Physical Activity for Selected Dysfunctions, with Particular Emphasis on Locomotive Organ Pain in Pregnant WomenImportance of Reducing Oxidative Stress, Full-Face Mask Use during SCUBA Diving Counters Related Oxidative Stress and Endothelial Dysfunction, Age-related characteristics of heart rate variability in patients with arterial hypertension: the effect of stress and habitual physical activity, Nicotinamide Riboside Supplementation for Treating Elevated Systolic Blood Pressure and Arterial Stiffness in Midlife and Older Adults, Six Months of Inspiratory Muscle Training to Lower Blood Pressure and Improve Endothelial Function in Middle-Aged and Older Adults With Above-Normal Blood Pressure and Obstructive Sleep Apnea: Protocol for the CHART Clinical Trial, Creative Commons AttributionNonCommercialNoDerivs, Copyright 2021 The Authors. S4). Cell Metab 2016;23:591-601. This database abstracts and indexes over 720 journals and provides full text for almost 550 of those titles. Overall, 94.3% of the participants completed the trial, 91.2% had a body-weight assessment at week 68, and 81.1% adhered to treatment (Fig. We observed a modest but clear difference in the prepost intervention changes in the overall plasma metabolite profiles of the IMST and sham groups. Search education literature and resources using the ERIC free public interface. Supportive secondary and exploratory end point analyses were not adjusted for multiplicity, and P values are therefore not reported for these end points. *The treatment policy estimand assesses treatment effect regardless of treatment discontinuation or rescue intervention; see Table S2 for corresponding data for the estimand (which assessed treatment effect assuming all participants adhered to treatment and did not receive rescue intervention). 7272 Greenville Ave. Finally, IMST was found to be safe, tolerable, and to promote excellent adherence. Talk with your doctor and family members or friends about deciding to join a study. Interested in having the most current science developments delivered to your email account every Monday? 2020 Dec 17;383(25):2439-2450. doi: 10.1056/NEJMoa2027906. Occurrence of nausea, vomiting and diarrhoea reported as adverse events in clinical trials studying glucagon-like peptide-1 receptor agonists: a systematic analysis of published clinical trials. NCJRS Abstracts Database contains abstracts/summaries for more than 195,000 resources. more. Friedrichsen M, Breitschaft A, Tadayon S, Wizert A, Skovgaard D. The effect of semaglutide 2.4 mg once weekly on energy intake, appetite, control of eating, and gastric emptying in adults with obesity. Includes links to free full text documents at the US GPO site. GreenFILE is provided free to academic subscribers. Newly enrolled participants enrolled to receive 2 doses of BNT162b2SA; male or female participants between the ages of 18 and 55 years, inclusive, at enrollment. All standard assays were performed in a central laboratory. In addition, the Professional Development Collection contains over 200 education reports. To establish the safety, adherence, and efficacy of highresistance IMST for lowering SBP and improving vascular function in midlife/older adults with abovenormal SBP, we conducted a randomized, doubleblind, shamcontrolled trial of highresistance IMST for 6weeks in adults aged 50 to 79years with baseline SBP 120mmHg. Few issues are more contentious in modern American life than mandatory mask orders. leaf extract on healthy volunteers. Curr Opin Cardiol 2011;26:555-561. Please do not edit the piece, ensure that you attribute the author and mention that this article was originally published on FEE.org. U.S. Department of Health and Human Services, The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. 5. In the semaglutide group, weight loss was observed from the first postrandomization assessment (week 4) onward, reaching a nadir at week 60 (Figure 1A and 1B). Intended for professional educators, librarians, and education researchers, the Professional Development Collection offers information on everything from children's health and development to cutting-edge pedagogical theory and practice. Whether adults with obesity can achieve weight loss with once-weekly semaglutide at a dose of 2.4 mg as an adjunct to lifestyle intervention has not been confirmed. ), and the Dallas Diabetes Research Center at Medical City (J.R.) both in Dallas; the Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia (T.A.W. Lornithine is a byproduct of the urea cycle and a precursor of Larginine,57 the substrate for NO production by eNOS, whereas greater circulating Lornithine could reflect increased substrate bioavailability and NO production with IMST. This the EBSCOhost interface to this security resource, JSTOR is a scholarly, full text journal archive with an integrated search and in addition a selection of e-books. Honestly, its careless to remove a mandate too soon, Ms. Buckman said in an interview. New York Times Digital Microfilm starts in 2008. 19. Mean 24hour DBP was unchanged in the IMST group (baseline: 752mmHg, endintervention: 742mmHg; P=0.63) and increased modestly in the sham group (baseline: 742mmHg, endintervention: 782mmHg; P=0.04). McCrimmon RJ, Catarig A-M, Frias JP, et al. Browse or search the full list of UC subscribed EbscoHost databases. ScienceDirect is one of the largest providers of scientific, technical and medical literature. Safety assessments included the number of adverse events occurring during the on-treatment period (the time during which participants received any dose of semaglutide or placebo within the previous 49 days, with any period of temporary interruption of the regimen excluded) and serious adverse events occurring between baseline and week 75. Access restricted to current Utica College Students, Faculty and Staff. BP was measured in triplicate, with 1minute between each measurement. Email: Highresistance inspiratory muscle strength training (IMST) is a novel, timeefficient physical training modality. Participants who received semaglutide had a greater improvement with respect to cardiometabolic risk factors and a greater increase in participant-reported physical functioning from baseline than those who received placebo. more. Percentage of participants in Phase 1 reporting local reactions [TimeFrame:For 7 days after dose 1 and dose 2], Percentage of participants in Phase 1 reporting systemic events [TimeFrame:For 7 days after dose 1 and dose 2], Percentage of participants in Phase 1 reporting adverse events [TimeFrame:From dose 1 through 1 month after the last dose], Percentage of participants in Phase 1 reporting serious adverse events [TimeFrame:From dose 1 through 6 months after the last dose], Percentage of Phase 1 participants with abnormal hematology and chemistry laboratory values [TimeFrame:1 day after dose 1], Percentage of Phase 1 participants with abnormal hematology and chemistry laboratory values [TimeFrame:7 days after dose 1], Percentage of Phase 1 participants with abnormal hematology and chemistry laboratory values [TimeFrame:7 days after dose 2], Percentage of Phase 1 participants with grading shifts in hematology and chemistry laboratory assessments [TimeFrame:Between baseline and 1 day after dose 1], Percentage of Phase 1 participants with grading shifts in hematology and chemistry laboratory assessments [TimeFrame:Between baseline and 7 days after dose 1], Percentage of Phase 1 participants with grading shifts in hematology and chemistry laboratory assessments [TimeFrame:Between before dose 2 and 7 days after dose 2], In the first 360 participants randomized into Phase 2/3, percentage of participants reporting local reactions [TimeFrame:For 7 days after dose 1 and dose 2], In the first 360 participants randomized into Phase 2/3, percentage of participants reporting systemic events [TimeFrame:For 7 days after dose 1 and dose 2], In the first 360 participants randomized into Phase 2/3, percentage of participants reporting adverse events [TimeFrame:From dose 1 through 1 month after the last dose], In the first 360 participants randomized into Phase 2/3, percentage of participants reporting serious adverse events [TimeFrame:From dose 1 through 6 months after the last dose], In a subset of at least 6000 participants randomized in Phase 2/3, percentage of participants reporting local reactions [TimeFrame:For 7 days after dose 1 and dose 2], In a subset of at least 6000 participants randomized in Phase 2/3, percentage of participants reporting systemic events [TimeFrame:For 7 days after dose 1 and dose 2], Percentage of participants in Phase 2/3 reporting adverse events [TimeFrame:From dose 1 through 1 month after the last dose], Percentage of participants in Phase 2/3 reporting serious adverse events [TimeFrame:From dose 1 through 6 months after the last dose], Confirmed COVID-19 in Phase 2/3 participants without evidence of infection before vaccination [TimeFrame:From 7 days after the second dose of study intervention to the end of the study, up to 2 years], Confirmed COVID-19 in Phase 2/3 participants with and without evidence of infection before vaccination [TimeFrame:From 7 days after the second dose of study intervention to the end of the study, up to 2 years], Percentage of participants 12-15 years of age in Phase 3 reporting adverse events [TimeFrame:From dose 1 through 1 month after the last dose], Percentage of participants 12-15 years of age in Phase 3 reporting adverse events [TimeFrame:From dose 1 through 6 months after the last dose], In participants 12-15 years of age randomized in Phase 3, percentage of participants reporting local reactions [TimeFrame:For 7 days after dose 1 and dose 2], In participants 12-15 years of age randomized in Phase 3, percentage of participants reporting systemic events [TimeFrame:For 7 days after dose 1 and dose 2], In participants who receive BNT162b2SA given as 1 or 2 doses, percentage of participants reporting adverse events [TimeFrame:From dose 1 through 1 month after the last dose], In participants who receive BNT162b2SA given as 1 or 2 doses, percentage of participants reporting serious adverse events [TimeFrame:From dose 1 through 5 or 6 months after the last dose], In participants, who receive BNT162b2SA given as 1 or 2 doses, percentage of participants reporting local reactions [TimeFrame:For 7 days after dose 1 (and dose 2)], In participants who receive BNT162b2SA given as 1 or 2 doses, percentage of participants reporting systemic events [TimeFrame:For 7 days after dose 1 (and dose 2)], In participants who receive a third dose of BNT162b2 as part of the subset for evaluation of boostability and protection against emerging VOCs, percentage of participants reporting adverse events [TimeFrame:From the third dose through 1 month after the third dose], In participants who receive a third dose of BNT162b2 as part of the subset for evaluation of boostability and protection against emerging VOCs, percentage of participants reporting serious adverse events [TimeFrame:From the third dose through 6 months after the third dose], In participants who receive a third dose of BNT162b2 as part of the subset for evaluation of boostability and protection against emerging VOCs, percentage of participants reporting local reactions [TimeFrame:For 7 days after the third dose], In participants who receive a third dose of BNT162b2 as part of the subset for evaluation of boostability and protection against emerging VOCs, percentage of participants reporting systemic events [TimeFrame:For 7 days after the third dose], In participants who receive a third dose of BNT162b2 as a result of current or anticipated recommendations, percentage of participants reporting adverse events [TimeFrame:From the third dose through 1 month after the third dose], In participants who receive a third dose of BNT162b2 as a result of current or anticipated recommendations, percentage of participants reporting serious adverse events [TimeFrame:From the third dose through 6 months after the third dose], Noninferiority of the SARS-CoV-2 reference strain neutralizing titers after a third dose of BNT162b2 at 30 g compared to after 2 doses of BNT162b2, in the same individuals [TimeFrame:1 month after the third dose], Noninferiority of the SARS-CoV-2 SA strain neutralizing titers after one dose of BNT162b2SA compared to the SARS-CoV-2 reference strain neutralizing titers after 2 doses of BNT162b2, in the same individuals [TimeFrame:1 month after the third dose], Noninferiority of the SARS-CoV-2 SA strain neutralizing titers after 2 doses of BNT162b2SA compared to the SARS-CoV-2 reference strain neutralizing titers after 2 doses of BNT162b2 [TimeFrame:1 month after the second dose], In Phase 1 participants, SARS-CoV-2 serum neutralizing antibody levels, expressed as GMTs [TimeFrame:Through 2 years after the final dose], In Phase 1 participants, GMFR in SARS-CoV-2 serum neutralizing titers from before vaccination to each subsequent time point [TimeFrame:Through 2 years after the final dose], Proportion of participants in Phase 1 achieving a greater than or equal to 4-fold rise from before vaccination in SARS-CoV-2 serum neutralizing antibody levels [TimeFrame:Through 2 years after the final dose], In Phase 1 participants, SARS-CoV-2 anti-S1 binding antibody levels and anti-RBD binding antibody levels, expressed as GMCs [TimeFrame:Through 2 years after the final dose], Proportion of participants in Phase 1 achieving a greater than or equal to 4-fold rise from before vaccination in SARS-CoV-2 anti-S1 binding antibody levels and anti-RBD binding antibody levels [TimeFrame:Through 2 years after the final dose], In Phase 1 participants, GMFR in SARS-CoV-2 anti-S1 binding antibody levels and anti-RBD binding antibody levels from before vaccination to each subsequent time point [TimeFrame:Through 2 years after the final dose], In Phase 1 participants, GMR of the geometric mean of SARS-CoV-2 serum neutralizing titers to the geometric mean of SARS CoV 2 (anti-S1 and anti-RBD) binding antibody levels [TimeFrame:Through 2 years after the final dose], Confirmed COVID-19 in Phase 2/3 participants without evidence of infection before vaccination [TimeFrame:From 14 days after the second dose of study intervention to the end of the study, up to 2 years], Confirmed COVID-19 in Phase 2/3 participants with and without evidence of infection before vaccination [TimeFrame:From 14 days after the second dose of study intervention to the end of the study, up to 2 years], Confirmed severe COVID-19 in Phase 2/3 participants without evidence of infection before vaccination [TimeFrame:From 7 days after the second dose of study intervention to the end of the study, up to 2 years], Confirmed severe COVID-19 in Phase 2/3 participants without evidence of infection before vaccination [TimeFrame:From 14 days after the second dose of study intervention to the end of the study, up to 2 years], Confirmed severe COVID-19 in Phase 2/3 participants with and without evidence of infection before vaccination [TimeFrame:From 7 days after the second dose of study intervention to the end of the study, up to 2 years], Confirmed severe COVID-19 in Phase 2/3 participants with and without evidence of infection before vaccination [TimeFrame:From 14 days after the second dose of study intervention to the end of the study, up to 2 years], Confirmed COVID-19 (according to the CDC-defined symptoms) in Phase 2/3 participants without evidence of infection before vaccination [TimeFrame:From 7 days after the second dose of study intervention to the end of the study, up to 2 years], Confirmed COVID-19 (according to the CDC-defined symptoms) in Phase 2/3 participants without evidence of infection before vaccination [TimeFrame:From 14 days after the second dose of study intervention to the end of the study, up to 2 years], Confirmed COVID-19 (according to the CDC-defined symptoms) in Phase 2/3 participants with and without evidence of infection before vaccination [TimeFrame:From 7 days after the second dose of study intervention to the end of the study, up to 2 years], Confirmed COVID-19 (according to the CDC-defined symptoms) in Phase 2/3 participants with and without evidence of infection before vaccination [TimeFrame:From 14 days after the second dose of study intervention to the end of the study, up to 2 years], GMR of SARS CoV 2 neutralizing titers in the 2 age groups (12-15 years of age to 16-25 years of age) [TimeFrame:1 month after the second dose], Incidence of asymptomatic SARS CoV-2 infection based on N binding antibody seroconversion in participants with no serological or virological evidence of past SARS CoV-2 infection or confirmed COVID-19 prior to 1 month after receipt of the second dose [TimeFrame:Through 1 month after the second dose], Incidence of asymptomatic SARS CoV-2 infection based on central laboratory-confirmed NAAT in participants with no serological or virological evidence (up to the start of the asymptomatic surveillance period) of past SARS-CoV-2 infection [TimeFrame:Through 6 months after the second dose], Noninferiority of the SARS-CoV-2 SA strain neutralizing titers after a third dose of BNT162b2 at 30 g compared to the SARS-CoV-2 reference strain neutralizing titers after 2 doses of BNT162b2, in the same individuals [TimeFrame:1 month after the third dose], Noninferiority of the SARS-CoV-2 reference strain neutralizing titers after one dose of BNT162b2SA compared to after 2 doses of BNT162b2, in the same individuals [TimeFrame:1 month after the first dose of BNT162b2SA], Comparison of the SARS-CoV-2 SA strain neutralizing titers after 1 dose of BNT162b2SA to after a third dose of BNT162b2 at 30 g [TimeFrame:1 month after the first dose of BNT162b2SA/third dose of BNT162b2], Comparison of the SARS-CoV-2 SA strain neutralizing titers after 2 doses of BNT162b2SA to the SARS-CoV-2 reference strain neutralizing titers after 2 doses of BNT162b2, in the same individuals [TimeFrame:1 month after the second dose of BNT162b2SA], Comparison of the SARS-CoV-2 SA strain neutralizing titers after 2 doses of BNT162b2SA to after 2 doses of BNT162b2 [TimeFrame:1 month after the second dose], Comparison of the SARS-CoV-2 reference strain neutralizing titers after 2 doses of BNT162b2SA to after 2 doses of BNT162b2 [TimeFrame:1 month after the second dose]. 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